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KMID : 0361020070500040341
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Korean Journal of Otolaryngology - Head and Neck Surgery
2007 Volume.50 No. 4 p.341 ~ p.345
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Altered Patterns of Melanoma Antigen Gene(MAGE) Expression in Benign, Premalignant and Malignant Epithelium of the Larynx
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Kim Jeong-Kyu
Park Gyu-Wook
Kim Ki-Yeong
Jeon Chang-Ho
Sohn Jin-Ho
Park June-Sik
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Abstract
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Background & Objectives: The degree of dysplasia of premalignant lesion of the larynx is related to malignant transformation. However, no single molecular marker that could be used to predict malignant transformation has been identified. Melanoma antigen genes (MAGE), which are expressed in malignant tissues but not in normal tissues, might provide such a marker. So, we investigated MAGE expressions in the various epithelial lesions of the larynx.
Subjects & Methods: Nested RT-PCR with MAGE common primers were performed to detect the expression of MAGE A genes in fresh frozen tissues obtained from laryngeal lesions (34 benign, 20 premalignant, 22 malignant epitheliums) and 12 normal oropharyngeal epitheliums.
Results: The expression of MAGE was positive in 12 (35.3%) of benign, 10 (50%) of premalignant, 18 (81.8%) of malignant laryngeal epithelium and 1 (8.5%) of normal epithelium. These expressions were different with statistic significance (p=0.003) between benign, premalignant and malignant laryngeal epithelium.
Conclusion: The MAGE A expression could be utilized as a biomarker to predict malignant transformation of laryngeal epithelium.
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KEYWORD
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MAGE, Precancerous condition, Tumor markers, Larynx
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